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A tiny pipette is used to inject a single sperm into the awaiting egg by ICSI

ICSI increases the fertilization rate for couples with poor semen quality and makes it possible for men with no measurable sperm in the ejaculate to father a biological child.

ICSI has revolutionized treatment for severe male factor infertility because the procedure requires only one healthy sperm to potentially achieve fertilization.

A variety of sperm problems can account for male infertility. Sperm can be completely absent in the ejaculate, a condition known as azoospermia. Men with low concentrations of sperm in the ejaculate have a condition known as oligospermia. Poor motility, or a condition called asthenospermia, occurs when the sperm do not have the forward swimming motion sufficient to make the journey from the ejaculation site in the female's vagina, though the reproductive tract, to unite with the egg in the fallopian tube. Men whose sperm have an increased percentage of abnormal shapes and forms have a diagnosis of teratospermia. Other sperm problems that prevent fertilization are abnormalities in the series of steps required for fertilization, such as the sperm's ability to bind and penetrate the cytoplasm of the egg.

In IVF with ICSI, a single sperm is injected into each mature egg. On average, about two thirds of the mature eggs that are injected with a sperm will fertilize.

 

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Last modified: 03/02/04